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Seagen

Senior Research Associate, Impurity Assays

Technical Operations & Process Sciences - Bothell, United States

Description

Seagen is a global, multi-product biotechnology company dedicated to developing and commercializing transformative cancer medicines. As the industry leader in antibody-drug conjugate (ADC) technology, we pioneered a new generation in the science of harnessing antibodies to deliver cell-killing agents directly to cancer cells. Seagen’s dedication to improving the lives of cancer patients goes beyond science, and we believe that every employee has a role in contributing to this mission. By working together with a shared dedication and diverse perspectives, we are able to reach our full potential and make a real difference in the world. Seagen is a fast-growing company and has an abundance of opportunities available for you to grow your career. Put your passion to work at Seagen and join us!

Summary:

Seagen is looking for a motivated Sr. Research Associate to work in the Impurity Assays Group. In this role, primary responsibilities include development, qualification, and sample testing of robust methods for process-related impurities including host cell proteins (e.g. enzymes), Protein A leachate, residual DNA, glucan, growth factors, etc. This individual will also participate in analytical method and reagent transfer activities to internal or external teams and manufacturing facilities. The ideal candidate will have a strong background in biochemistry, molecular biology, or related disciplines, excellent critical thinking and troubleshooting skills, experience collaborating on cross-functional teams, and the ability to work both independently and in a collaborative manner.

Principal Responsibilities:

  • Design and perform complex experiments, propose new experiments, and implement new ideas to characterize process-related impurities. Includes development and qualification of analytical methods
  • Initiate and complete work, followed by analysis and reduction of data to conclusions with minimal supervision. Design subsequent experiments upon interpretation of data.
  • Take responsibility for long-term projects or for components within major projects
  • Support transfer of methods and reagents to internal or external teams and manufacturing facilities
  • May contribute to regulatory submissions, patents, and publications
  • Serve as a subject matter expert in one or more technical areas within functional area
  • Lead functional area teams. May represent functional area and related functions on cross-functional teams
  • Present to department and to cross-functional teams. May give presentations or present posters externally at conferences. Actively participate in group discussions and author technical reports

Required Qualifications:

  • B.S. (8+ years relevant industry experience) or M.S. (5+ years) degree in biochemistry, chemistry, molecular biology, or other life science
  • Familiarity with process development for drug manufacturing
  • Proficiency in plate-based assay development and troubleshooting, including ELISAs and enzyme assays
  • Experience with gel electrophoresis and western blotting
  • Experience in method qualification/validation
  • Strong organizational skill and attention to detail
  • Demonstrated ability to understand project scope and meet deliverable timelines
  • Proactive communication and interpersonal skills

Preferred Qualifications:

  • Knowledge of or experience with CMC activities in early or late phase setting
  • Awareness of PCR methods for DNA quantitation
  • Experience with lab automation technologies
  • Interest to informally mentor junior staff

As the leading employer in our industry in the Pacific Northwest, Seagen is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seagen, please visit www.seagen.com.

The hiring pay range for this position is $94,000 to $122,000 per year based on skills, education and experience relevant to the role. Other components of total compensation include a competitive equity grant at the time of hire (with additional annual grants, and grants upon promotion when applicable), and an annual bonus.

Seagen is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.

Apply:


Seagen

Seagen is an Equal Opportunity Employer

Submitted: 03/11/2023

Lundbeck Seattle BioPharmaceuticals Lundbeck -- tirelessly dedicated to restoring brain health.




















 
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